Developing combinatorial multi-component therapies (CMCT) of drugs that are more specific and have fewer side effects than traditional one drug therapies

Larry S Liebovitch¹ , Nicholas Tsinoremas² and Abhijit Pandya³

¹Florida Atlantic University, Center for Complex Systems and Brain Sciences, Center for Molecular Biology and Biotechnology, Department of Psychology, Department of Biomedical Science, Boca Raton, FL 33431, USA

²The Scripps Research Institute, Scripps Florida, Informatics, Jupiter FL 33458, USA

³Florida Atlantic University, Department of Computer Science and Engineering, Boca Raton, FL 33431, USA

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Nonlinear Biomedical Physics 2007, 1:11doi:10.1186/1753-4631-1-11


Published:	30 August 2007

Abstract

Drugs designed for a specific target are always found to have multiple effects. Rather than hope that one bullet can be designed to hit only one target, nonlinear interactions across genomic and proteomic networks could be used to design Combinatorial Multi-Component Therapies (CMCT) that are more targeted with fewer side effects. We show here how computational approaches can be used to predict which combinations of drugs would produce the best effects. Using a nonlinear model of how the output effect depends on multiple input drugs, we show that an artificial neural network can accurately predict the effect of all 2¹⁵= 32,768 combinations of drug inputs using only the limited data of the output effect of the drugs presented one-at-a-time and pairs-at-a-time.